Indian Journal of Dentistry
Volume 2, Issue 2 , Pages 1-7, June 2011

Alterations in serum lipid profile patterns in oral cancer and oral precancerous lesions and conditions—a clinical study

  • Shally Gupta, MDS

      Affiliations

    • Professor and Head, Department of Oral and Maxillofacial Pathology, Panjab University, Chandigarh
    • ,
  • Shipra Gupta, MDS

      Affiliations

    • Associate Professor, Department of Periodontics, Dr. HS Judge Institute of Dental Sciences, Panjab University, Chandigarh
    • Corresponding Author InformationCorrespondence: Dr. Shipra Gupta, House Number 1472, Near Government Dispensary, Sector 21, Panchkula, Haryana

Received 12 April 2011; accepted 10 May 2011.

Article Outline

Abstract 

Introduction

Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucus fibrosis (OSMF), oral leukoplakia, and oral lichen planus, with respect to healthy controls and proven cases of oral squamous cell carcinoma.

Materials and Method

In this hospital-based study, 25 clinically diagnosed and histopathologically proven patients of oral squamous cell carcinoma and 15 healthy controls were compared with 15 patients each of OSMF, leukoplakia, and lichen planus. In these groups, serum lipids including: (i) total cholesterol, (ii) high density lipoprotein cholesterol (HDLC), and (iii) triglycérides were analyzed.

Results

A significant decrease in plasma total cholesterol, HDLC, and triglycerides was observed in the patients with the precancerous lesions and conditions as compared to the controls. Thus, an inverse relationship between plasma lipid levels and patients was found. However, they had higher levels of cholesterol and lower levels of HDLC and triglycérides as compared to the oral squamous cell carcinoma group.

Conclusion

The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous lesions and conditions.

Keywords:  Cholesterol , head and neck cancer , leukoplakia , lichen planus , oral submucus fibrosis

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Murti PR , Bhonsle RB , Pindborg JJ , Daftary DK , Gupta PC , Mehta FS . Malignant transformation rate in oral submucous fibrosis over a 17-year period . Community Dent Oral Epidemiol . 1985;13:340–341
  2. Pindborg JJ , Jolst O , Renstrup G , Roed-Petersen B . Studies in oral leukoplakia: a preliminary report on the period prevalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients . J Am Dent Assoc . 1968;76:767–771
  3. Axell T , Pindborg JJ , Smith CJ , van der Waal I . Oral white lesions with special reference to precancerous and tobacco related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21, 1994. International Collaborative Group on Oral White Lesions . J Oral Oral Pathol Med . 1996;25:49–54
  4. Mehta FS , Pindborg JJ , Gupta PC , Daftary DK . Epidemiologic and histologic study of oral cancer and leukoplakia among 50915 villagers in India . Cancer . 1969;24:832–849
  5. Andreasen JO . Oral lichen planus. 1. A clinical evaluation of 115 cases . Oral Surg Oral Med Oral Pathol . 1968;25:31–42
  6. Krutchkoff DJ , Cutler L , Laskowski S . Oral lichen planus: the evidence regarding potential malignant transformation . J Oral Pathol . 1978;7:1–7
  7. Tyldesley WR . Malignant transformation in oral lichen planus . Br Dent J . 1982;153:329–330
  8. Pogrel MA , Weldon LL . Carcinoma arising in erosive lichen planus in the midline of the dorsum of the tongue . Oral Surg Oral Med Oral Pathol . 1983;55:62–66
  9. Odukoya O , Gallagher G , Shklar G . A histologic study of epithelial dysplasia in oral lichen planus . Arch Dermatol . 1985;121:1132–1136
  10. Shafer WG , Hine MG , Levy BM . In: A Textbook of Oral Pathology . 4th ed.. Philadelphia: WB Saunders; 1993;p. 109–110
  11. Shah B , Lewis MA , Bedi R . Oral submucous fibrosis in a 11-year-old Bangladeshi girl living in United Kingdom . Br Dent J . 2001;191:130–132
  12. Tilakaratne WM , Klinikowski MF , Saku T , Peters TJ , Warnakulasuriya S . Oral submucous fibrosis: review on aetiology and pathogenesis . Oral Oncol . 2006;42:561–568
  13. Chang YC , Hu CC , Tseng TH , Tai KW , Lii CK , Chou MY . Synergetic effect of nicotine on arecoline induced cytotoxicity in human buccal mucosa fibroblasts . J Oral Pathol Med . 2001;30:458–464
  14. Manoharan S , Kolanjiappan K , Suresh K , Panjamurthy K . Lipid peroxidation and antioxidants status in patients with oral squamous cell carcinoma . Indian J Med Res . 2005;122:529–534
  15. Rajendran R . Oral submucous fibrosis: etiology, pathogenesis and future research . Bull WHO . 1994;72:985–996
  16. Berlin NI . Tumour markers in cancer prevention and detection . Cancer . 1981;47(5 Suppl):1151–1153
  17. Forones NM , Falcao JB , Mattos D , Barone B . Cholesterolemia in colorectal cancer . Hepatogastroenterology . 1998;45:1531–1534
  18. Chyou PH , Nomura AM , Stemmermann GN , Kato I . Prospective study of serum cholesterol and site-specific cancers . J Clin Epidemiol . 1992;45:287–292
  19. Patel PS , Shah MH , Jha FP , Raval GN , Rawal RM , Patel MM , et al.   Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions . Indian J Cancer . 2004;41:25–31
  20. Fredrickson DS , Levy RI . Familial hyperlipoproteinemia . In:  Stanbury JB ,  Wyngaarden JB ,  Fredrickson DS editor. The Metabolic Basis of Inherited Disease . 3rd ed.. New York: McGraw-Hill Book Co.; 1972;
  21. Tietz NW . Fundamentals of Clinical Chemistry . Philadelphia, USA: WB Saunders Company; 1994;
  22. Kaul D . Do human platelets possess LDL-receptor specific for apoprotein ‘B’ or cholesterol? . Curr Scl . 1993;65:883–886
  23. Kaul D . Receptor-Ck and leukemogenesis . Leuk Res . 1998;22:389–394
  24. Kaul D , Kaur M . Receptor-Ck regulates the expression of cyclindependent kinase inhibitors . Mol Cell Biochem . 1999;200:183–186
  25. Kaur M , Kaul D , Sobti RC . Receptor-Ck dependent regulation of genes involved in the cell cycle . Mol Cell Biochem . 1998;181:137–142
  26. Kaul D , Khosla VK . Molecular basis of ‘cholesterol feedback lesion’ in CNS tumors . Neurol India . 2000;48:174–177
  27. Kritchevsky SB , Wilcosky TC , Morris DL , Truong KN , Tyroler HA . Changes in plasma lipid and lipoprotein cholesterol and weight prior to the diagnosis of cancer . Cancer Res . 1991;51:3198–3203
  28. Kesaniemi YA , Witzlum JL , Steinbrecher UP . Receptor-mediated catabolism of low density lipoprotein in man. Quantitation using glycosylated lipoprotein . J Clin Invest . 1983;71:950–959
  29. Brown MS , Kovanen PT , Goldstein JL . Regulation of plasma cholesterol by lipoprotein receptors . Science . 1981;212:628–635
  30. Allampallam K , Dutt D , Nair C , et al.   The clinical and biologic significance of abnormal lipid profiles in patients with myelodysplastic syndromes . J Hematother Stem Cell Res . 2000;9:247–255
  31. Dessi S , Batetta B , Pulisci D , et al.   Altered pattern of lipid metabolism in patients with lung cancer . Oncology . 1992;49:436–441
  32. Mehrotra R , Pandya S , Chaudhary AK , et al.   Lipid profile in oral submucous fibrosis . Lipids Health Dis . 2009;8:29
  33. Schatzkin A , Hoover RN , Taylor PR , et al.   Site-specific analysis of total serum cholesterol and incident cancers in the National Health and Nutrition Examination Survey I epidemiologic follow-up study . Cancer Res . 1988;48:452–458
  34. Williams RR , Sorlie PD , Feinleib M , McNamara PM , Kannel WB , Dawber TR . Cancer incidence by levels of cholesterol . JAMA . 1981;245:247–252
  35. Feinleib M . Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer . Cancer Res . 1983;43(5 Suppl):2503s–2507s
  36. Silverman S , Gorsky M , Lozada-Nur F . A prospective follow-up of study of 570 patients with oral lichen planus: persistance, remission, and malignant transformation . Oral Surg Oral Med Oral Pathol . 1985;60:30–34
  37. Tulinius H . Late determinants of cancer . Pathol Res Pract . 1984;179:74–80
  38. Broitman SA . Dietary cholesterol, serum cholesterol and colon cancer: a review . Adv Exp Med Biol . 1986;206:137–152
  39. D'Antonio JA , LaPorte RE , Dai WS , Hom DL , Wozniczak M , Kuller LH . Lipoprotein cholesterol, vitamin A, and vitamin E in an alcoholic population . Cancer . 1986;57:1798–1802
  40. Knekt P , Reunanen A , Aromaa A , Heliovaara M , Hakulinen T , Hakama M . Serum cholesterol and risk of cancer in a cohort of 39,000 men and women . J Clin Epidemiol . 1988;41:519–530
  41. Dianzani MU . Lipid peroxidation and cancer: a critical reconsideration . Tumori . 1989;75:351–357
  42. Morin RJ , Hu B , Peng SK , Sevanian A . Cholesterol oxides and carcinogenesis . J Clin Lab Anal . 1991;5:219–225
  43. Høyer AP , Engholm G . Serum lipids and breast cancer risk-a cohort study of 5207 Danish women . Cancer Causes Control . 1992;3:403–408
  44. Kritchevsky SB , Kritchevsky D . Serum cholesterol and cancer risk-an epidemiologic perspective . Annu Rev Nutr . 1992;12:391–416

PII: S0975-962X(11)60002-6

doi:10.1016/S0975-962X(11)60002-6

Indian Journal of Dentistry
Volume 2, Issue 2 , Pages 1-7, June 2011

Article Tools